Synthetic biology, artificial intelligence+biological reactions, mechanical stirring, pilot scale, strain optimization ...
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- Issue Time
- Jun 16,2025
Summary
Synthetic biology, artificial intelligence+biological reactions
Hyaluronic acid (HA), also known as hyaluronic acid, is a linear polysaccharide formed by alternating connections of N-acetylglucosamine and D-glucuronic acid. It is widely present in human skin, joints, and other tissues, and has excellent moisturizing, repairing, and anti-aging functions.
1、 Medical beauty application scenarios
Small molecule HA (<500kDa): infiltrates into the dermis, promotes collagen regeneration, and is used for deep water supplement such as Shuiguang needle and essence liquid to improve dryness and fine lines. The effect lasts for 4-6 months.
Medium molecular weight HA (500-1500kDa): with a slightly soft texture, it fills soft tissues such as tear troughs and temples, and also has anti-inflammatory effects, lasting 6-12 months.
High molecular weight HA (>1500kDa): forms a physical support network for deep filling such as nose augmentation and buttock augmentation, improving contour stability, and the effect can last for 12-18 months.
2、 Breakthrough in Microbial Fermentation
Strain optimization: For example, the team from Jiangnan University used ARTP mutagenesis technology to modify Streptococcus suis, obtaining a high-yield mutant strain mut-A17. The shaking bottle yield increased by 42.9% to 0.813g/L, and the 5L tank fermentation reached 4.56g/L after 20 hours, significantly shortening the production cycle.
Synthetic biology applications: for example, using CRISPR technology to regulate metabolic pathways, enhance the supply of precursor UDP glucuronic acid, and further increase HA production.
3、 Market situation
In 2023, the market size of HA raw materials in China will reach 4.71 billion yuan, and it is expected to exceed 10 billion yuan by 2025, with a compound annual growth rate of over 20%. The medical beauty field accounts for 47.5%, and injection products contribute 2.5%.
